Mct8-Deficient Mice Have Increased Energy Expenditure and Reduced Fat Mass That Is Abrogated by Normalization of Serum T(3) Levels

Children with monocarboxylate transporter 8 (MCT8) deficiency lose weight, even when adequately nourished. Changes in serum markers of thyroid hormone (TH) action compatible with thyrotoxicosis suggested that this might be due to T(3) excess in peripheral tissues. Mct8-deficient mice (Mct8KO) replic...

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Autors principals: Di Cosmo, Caterina, Liao, Xiao-Hui, Ye, Honggang, Ferrara, Alfonso Massimiliano, Weiss, Roy E., Refetoff, Samuel, Dumitrescu, Alexandra M.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2013
Matèries:
Thyroid-TRH-TSH
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836073/
https://ncbi.nlm.nih.gov/pubmed/24029243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1150
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