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Cytosolic PrP Can Participate in Prion-Mediated Toxicity
Prion diseases are characterized by a conformational change in the normal host protein PrPC. While the majority of mature PrPC is tethered to the plasma membrane by a glycosylphosphatidylinositol anchor, topological variants of this protein can arise during its biosynthesis. Here we have generated D...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4097767/ https://ncbi.nlm.nih.gov/pubmed/24807727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00732-14 |
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