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Interference with Ubiquitination in CFTR Modifies Stability of Core Glycosylated and Cell Surface Pools

It is recognized that both wild-type and mutant CFTR proteins undergo ubiquitination at multiple lysines in the proteins and in one or more subcellular locations. We hypothesized that ubiquitin is added to specific sites in wild-type CFTR to stabilize it and at other sites to signal for proteolysis....

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Bibliografski detalji
Glavni autori: Lee, Seakwoo, Henderson, Mark J., Schiffhauer, Eric, Despanie, Jordan, Henry, Katherine, Kang, Po Wei, Walker, Douglas, McClure, Michelle L., Wilson, Landon, Sorscher, Eric J., Zeitlin, Pamela L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097669/
https://ncbi.nlm.nih.gov/pubmed/24777605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01042-13
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