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S-palmitoylation regulates biogenesis of core glycosylated wild-type and F508del CFTR in a post-ER compartment
Defects in CFTR maturation are central to the pathogenesis of cystic fibrosis (CF). Palmitoylation serves as a key regulator of maturational processing in other integral membrane proteins, but has not been tested previously for functional effects on CFTR. In this study, we used metabolic labeling to...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3993085/ https://ncbi.nlm.nih.gov/pubmed/24475974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20131037 |
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