Fbw7 Targets GATA3 through Cyclin-Dependent Kinase 2-Dependent Proteolysis and Contributes to Regulation of T-Cell Development

Proper development of T cells depends on lineage-specific regulators controlled transcriptionally and posttranslationally to ensure precise levels at appropriate times. Conditional inactivation of F-box protein Fbw7 in mouse T-cell development resulted in reduced thymic CD4 single-positive (SP) and...

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Auteurs principaux: Kitagawa, Kyoko, Shibata, Kiyoshi, Matsumoto, Akinobu, Matsumoto, Masaki, Ohhata, Tatsuya, Nakayama, Keiichi I., Niida, Hiroyuki, Kitagawa, Masatoshi
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2014
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097664/
https://ncbi.nlm.nih.gov/pubmed/24820417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01549-13
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