Clostridium difficile Toxin A Attenuates Wnt/β-Catenin Signaling in Intestinal Epithelial Cells

Clostridium difficile toxins A and B (TcdA and TcdB) are homologous glycosyltransferases that inhibit a group of small GTPases within host cells, but several mechanisms underlying their pathogenic activity remain unclear. In this study, we evaluated the effects of TcdA on the Wnt/β-catenin pathway,...

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Detalhes bibliográficos
Main Authors: Bezerra Lima, Bruno, Faria Fonseca, Bárbara, da Graça Amado, Nathália, Moreira Lima, Débora, Albuquerque Ribeiro, Ronaldo, Garcia Abreu, José, de Castro Brito, Gerly Anne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097644/
https://ncbi.nlm.nih.gov/pubmed/24711571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00567-13
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