Clostridioides difficile Toxin A-Induced Wnt/β-Catenin Pathway Inhibition Is Mediated by Rac1 Glucosylation

Clostridioides difficile toxin A (TcdA) has been shown to inhibit cellular Wnt signaling, the major driving force behind the proliferation of epithelial cells in colonic crypts, likely through the inhibition of β-catenin nuclear translocation. Herein, we aimed to advance the understanding of this me...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Microbiol
Auteurs principaux: Martins, Conceição S., Costa, Deiziane V. S., Lima, Bruno B., Leitäo, Renata F. C., Freire, Gildênio E., Silva, Guilherme F. M., Pacífico, Dvison M., Abreu, José G., Brito, Gerly A. C.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2020
Sujets:
Microbiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483921/
https://ncbi.nlm.nih.gov/pubmed/32983019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2020.01998
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