Clostridioides difficile Toxin A-Induced Wnt/β-Catenin Pathway Inhibition Is Mediated by Rac1 Glucosylation

Clostridioides difficile toxin A (TcdA) has been shown to inhibit cellular Wnt signaling, the major driving force behind the proliferation of epithelial cells in colonic crypts, likely through the inhibition of β-catenin nuclear translocation. Herein, we aimed to advance the understanding of this me...

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Detalles Bibliográficos
Publicado en:Front Microbiol
Autores principales: Martins, Conceição S., Costa, Deiziane V. S., Lima, Bruno B., Leitäo, Renata F. C., Freire, Gildênio E., Silva, Guilherme F. M., Pacífico, Dvison M., Abreu, José G., Brito, Gerly A. C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Microbiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483921/
https://ncbi.nlm.nih.gov/pubmed/32983019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2020.01998
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