Proteasome Inhibitors Evoke Latent Tumor Suppression Programs in Pro-B MLL Leukemias Through MLL-AF4

Chromosomal translocations disrupting MLL generate MLL-fusion proteins that induce aggressive leukemias. Unexpectedly, MLL-fusion proteins are rarely observed at high levels, suggesting excessive MLL-fusions may be incompatible with a malignant phenotype. Here, we used clinical proteasome inhibitors...

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Huvudupphovsmän: Liu, Han, Westergard, Todd D., Cashen, Amanda, Piwnica-Worms, David R., Kunkle, Lori, Vij, Ravi, Pham, Can G., DiPersio, John, Cheng, Emily H., Hsieh, James J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097146/
https://ncbi.nlm.nih.gov/pubmed/24735925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.03.008
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