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Restoring MLL reactivates latent tumor suppression-mediated vulnerability to proteasome inhibitors
MLL undergoes multiple distinct chromosomal translocations to yield aggressive leukemia with dismal outcomes. Besides their well-established role in leukemogenesis, MLL fusions also possess latent tumor-suppressive activity, which can be exploited as effective cancer treatment strategies using pharm...
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| Опубликовано в: : | Oncogene |
|---|---|
| Главные авторы: | , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7471105/ https://ncbi.nlm.nih.gov/pubmed/32733069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01408-7 |
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