Restoring MLL reactivates latent tumor suppression-mediated vulnerability to proteasome inhibitors

MLL undergoes multiple distinct chromosomal translocations to yield aggressive leukemia with dismal outcomes. Besides their well-established role in leukemogenesis, MLL fusions also possess latent tumor-suppressive activity, which can be exploited as effective cancer treatment strategies using pharm...

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Foilsithe in:Oncogene
Main Authors: Ge, Maolin, Li, Dan, Qiao, Zhi, Sun, Yan, Kang, Ting, Zhu, Shouhai, Wang, Shifen, Xiao, Hua, Zhao, Chunjun, Shen, Shuhong, Xu, Zhenshu, Liu, Han
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2020
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7471105/
https://ncbi.nlm.nih.gov/pubmed/32733069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01408-7
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