Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

Reprogramming of pancreatic exocrine cells into cells resembling beta cells may provide a strategy for treating diabetes. Here we show that transient administration of epidermal growth factor and ciliary neurotrophic factor to adult mice with chronic hyperglycemia efficiently stimulates the conversi...

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Detalhes bibliográficos
Main Authors: Baeyens, Luc, Lemper, Marie, Leuckx, Gunter, De Groef, Sofie, Bonfanti, Paola, Stangé, Geert, Shemer, Ruth, Nord, Christoffer, Scheel, David W., Pan, Fong C., Ahlgren, Ulf, Gu, Guoqiang, Stoffers, Doris A., Dor, Yuval, Ferrer, Jorge, Gradwohl, Gerard, Wright, Christopher VE, Van de Casteele, Mark, German, Michael S., Bouwens, Luc, Heimberg, Harry
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096987/
https://ncbi.nlm.nih.gov/pubmed/24240391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2747
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