Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

Reprogramming of pancreatic exocrine cells into cells resembling beta cells may provide a strategy for treating diabetes. Here we show that transient administration of epidermal growth factor and ciliary neurotrophic factor to adult mice with chronic hyperglycemia efficiently stimulates the conversi...

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Autors principals: Baeyens, Luc, Lemper, Marie, Leuckx, Gunter, De Groef, Sofie, Bonfanti, Paola, Stangé, Geert, Shemer, Ruth, Nord, Christoffer, Scheel, David W., Pan, Fong C., Ahlgren, Ulf, Gu, Guoqiang, Stoffers, Doris A., Dor, Yuval, Ferrer, Jorge, Gradwohl, Gerard, Wright, Christopher VE, Van de Casteele, Mark, German, Michael S., Bouwens, Luc, Heimberg, Harry
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096987/
https://ncbi.nlm.nih.gov/pubmed/24240391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2747
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