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Evaluating N-benzylgalactonoamidines as putative transition state analogs for β-galactoside hydrolysis
Experimental evidence is provided for p-methylbenzyl-D-galactonoamidine to function as a true transition state analog for the enzymatic hydrolysis of aryl-β-D-galactopyranosides by β-galactosidase (A. oryzae). The compound exhibits inhibition constants in the low nanomolar concentration range (12–56...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4096895/ https://ncbi.nlm.nih.gov/pubmed/24668069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4ob00153b |
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