Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma

Sonic hedgehog (Shh), a soluble ligand overexpres sed by neoplastic cells in pancreatic ductal adenocarcinoma (PDAC), drives formation of a fibroblast-rich desmoplastic stroma. To better understand its role in malignant progression, we deleted Shh in a well-defined mouse model of PDAC. As predicted,...

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Autors principals: Rhim, Andrew D., Oberstein, Paul E., Thomas, Dafydd H., Mirek, Emily T., Palermo, Carmine F., Sastra, Steve A., Dekleva, Erin N., Saunders, Tyler, Becerra, Claudia P, Tattersall, Ian W., Westphalen, C. Benedikt, Kitajewski, Jan, Fernandez-Barrena, Maite G., Fernandez-Zapico, Martin E., Iacobuzzio-Donahue, Christine, Olive, Kenneth P., Stanger, Ben Z.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096698/
https://ncbi.nlm.nih.gov/pubmed/24856585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.04.021
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