Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma

Sonic hedgehog (Shh), a soluble ligand overexpres sed by neoplastic cells in pancreatic ductal adenocarcinoma (PDAC), drives formation of a fibroblast-rich desmoplastic stroma. To better understand its role in malignant progression, we deleted Shh in a well-defined mouse model of PDAC. As predicted,...

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書誌詳細
主要な著者: Rhim, Andrew D., Oberstein, Paul E., Thomas, Dafydd H., Mirek, Emily T., Palermo, Carmine F., Sastra, Steve A., Dekleva, Erin N., Saunders, Tyler, Becerra, Claudia P, Tattersall, Ian W., Westphalen, C. Benedikt, Kitajewski, Jan, Fernandez-Barrena, Maite G., Fernandez-Zapico, Martin E., Iacobuzzio-Donahue, Christine, Olive, Kenneth P., Stanger, Ben Z.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096698/
https://ncbi.nlm.nih.gov/pubmed/24856585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.04.021
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