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Activity and Architecture of Pyroglutamate-Modified Amyloid-β (Aβ(pE3-42)) Pores

[Image: see text] Among the family of Aβ peptides, pyroglutamate-modified Aβ (Aβ(pE)) peptides are particularly associated with cytotoxicity in Alzheimer’s disease (AD). They represent the dominant fraction of Aβ oligomers in the brains of AD patients, but their accumulation in the brains of elderly...

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Bibliografiset tiedot
Päätekijät: Gillman, Alan L., Jang, Hyunbum, Lee, Joon, Ramachandran, Srinivasan, Kagan, Bruce L., Nussinov, Ruth, Teran Arce, Fernando
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2014
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096221/
https://ncbi.nlm.nih.gov/pubmed/24922585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp5040954
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