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Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in ER stress
Production of bile by the liver is crucial for the absorption of lipophilic nutrients. Dysregulation of bile acid homeostasis can lead to cholestatic liver disease and ER stress. We show using global location analysis (“ChIP-on-Chip”) and cell-type specific gene ablation that the winged helix transc...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4095974/ https://ncbi.nlm.nih.gov/pubmed/18660816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1853 |
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