Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

Gene regulation relies on transcription factors (TFs) exploring the nucleus searching their targets. So far, most studies have focused on how fast TFs diffuse, underestimating the role of nuclear architecture. We implemented a single-molecule tracking assay to determine TFs dynamics. We found that c...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Izeddin, Ignacio, Récamier, Vincent, Bosanac, Lana, Cissé, Ibrahim I, Boudarene, Lydia, Dugast-Darzacq, Claire, Proux, Florence, Bénichou, Olivier, Voituriez, Raphaël, Bensaude, Olivier, Dahan, Maxime, Darzacq, Xavier
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2014
Gaiak:
Biophysics and Structural Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4095940/
https://ncbi.nlm.nih.gov/pubmed/24925319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02230
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