Probing the target search of DNA-binding proteins in mammalian cells using TetR as model searcher

Many cellular functions rely on DNA-binding proteins finding and associating to specific sites in the genome. Yet the mechanisms underlying the target search remain poorly understood, especially in the case of the highly organized mammalian cell nucleus. Using as a model Tet repressors (TetRs) searc...

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發表在:Nat Commun
Main Authors: Normanno, Davide, Boudarène, Lydia, Dugast-Darzacq, Claire, Chen, Jiji, Richter, Christian, Proux, Florence, Bénichou, Olivier, Voituriez, Raphaël, Darzacq, Xavier, Dahan, Maxime
格式: Artigo
語言:Inglês
出版: Nature Pub. Group 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507003/
https://ncbi.nlm.nih.gov/pubmed/26151127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8357
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