Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

Gene regulation relies on transcription factors (TFs) exploring the nucleus searching their targets. So far, most studies have focused on how fast TFs diffuse, underestimating the role of nuclear architecture. We implemented a single-molecule tracking assay to determine TFs dynamics. We found that c...

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Detaylı Bibliyografya
Asıl Yazarlar: Izeddin, Ignacio, Récamier, Vincent, Bosanac, Lana, Cissé, Ibrahim I, Boudarene, Lydia, Dugast-Darzacq, Claire, Proux, Florence, Bénichou, Olivier, Voituriez, Raphaël, Bensaude, Olivier, Dahan, Maxime, Darzacq, Xavier
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2014
Konular:
Biophysics and Structural Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4095940/
https://ncbi.nlm.nih.gov/pubmed/24925319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02230
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