Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

Gene regulation relies on transcription factors (TFs) exploring the nucleus searching their targets. So far, most studies have focused on how fast TFs diffuse, underestimating the role of nuclear architecture. We implemented a single-molecule tracking assay to determine TFs dynamics. We found that c...

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Detalhes bibliográficos
Main Authors: Izeddin, Ignacio, Récamier, Vincent, Bosanac, Lana, Cissé, Ibrahim I, Boudarene, Lydia, Dugast-Darzacq, Claire, Proux, Florence, Bénichou, Olivier, Voituriez, Raphaël, Bensaude, Olivier, Dahan, Maxime, Darzacq, Xavier
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Biophysics and Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4095940/
https://ncbi.nlm.nih.gov/pubmed/24925319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02230
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