Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

Gene regulation relies on transcription factors (TFs) exploring the nucleus searching their targets. So far, most studies have focused on how fast TFs diffuse, underestimating the role of nuclear architecture. We implemented a single-molecule tracking assay to determine TFs dynamics. We found that c...

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Bibliografiska uppgifter
Huvudupphovsmän: Izeddin, Ignacio, Récamier, Vincent, Bosanac, Lana, Cissé, Ibrahim I, Boudarene, Lydia, Dugast-Darzacq, Claire, Proux, Florence, Bénichou, Olivier, Voituriez, Raphaël, Bensaude, Olivier, Dahan, Maxime, Darzacq, Xavier
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2014
Ämnen:
Biophysics and Structural Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4095940/
https://ncbi.nlm.nih.gov/pubmed/24925319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02230
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