VEGFR3 Inhibition Chemosensitizes Ovarian Cancer Stemlike Cells through Down-Regulation of BRCA1 and BRCA2()()

In ovarian cancer, loss of BRCA gene expression in tumors is associated with improved response to chemotherapy and increased survival. A means to pharmacologically downregulate BRCA gene expression could improve the outcomes of patients with BRCA wild-type tumors. We report that vascular endothelial...

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Autores principales: Lim, Jaeyoung, Yang, Kun, Taylor-Harding, Barbie, Wiedemeyer, W. Ruprecht, Buckanovich, Ronald J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Neoplasia Press 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094836/
https://ncbi.nlm.nih.gov/pubmed/24862760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2014.04.003
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