BRCA1-associated epigenetic regulation of p73 mediates an effector pathway for chemosensitivity in ovarian carcinoma

The majority of tumors arising in BRCA1 mutation carriers exhibit inactivation of p53, a key effector of cell death following DNA damage. Despite the loss of p53, BRCA1-deficient tumor cells exhibit increased sensitivity to cisplatin, and patients with BRCA1-associated ovarian carcinomas experience...

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Main Authors: Ibrahim, Nageatte, He, Lei, Leong, Chee-Onn, Xing, Deyin, Karlan, Beth Y., Swisher, Elizabeth M., Rueda, Bo R., Orsulic, Sandra, Ellisen, Leif W.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940979/
https://ncbi.nlm.nih.gov/pubmed/20807817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0668
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