BRCA1-associated epigenetic regulation of p73 mediates an effector pathway for chemosensitivity in ovarian carcinoma

The majority of tumors arising in BRCA1 mutation carriers exhibit inactivation of p53, a key effector of cell death following DNA damage. Despite the loss of p53, BRCA1-deficient tumor cells exhibit increased sensitivity to cisplatin, and patients with BRCA1-associated ovarian carcinomas experience...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Ibrahim, Nageatte, He, Lei, Leong, Chee-Onn, Xing, Deyin, Karlan, Beth Y., Swisher, Elizabeth M., Rueda, Bo R., Orsulic, Sandra, Ellisen, Leif W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940979/
https://ncbi.nlm.nih.gov/pubmed/20807817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0668
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi