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Association of BRCA1- and BRCA2-deficiency with mutation burden, expression of PD-L1/PD-1, immune infiltrates, and T cell-inflamed signature in breast cancer

Immune checkpoint inhibitors have demonstrated effective anti-tumour response in cancer types with high mutation burden (e.g. melanoma) and in subset of cancers with features of genomic instability (e.g. mismatch-repair deficiency). One possible explanation for this effect is the increased expressio...

詳細記述

保存先:
書誌詳細
出版年:PLoS One
主要な著者: Wen, Wei Xiong, Leong, Chee-Onn
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483182/
https://ncbi.nlm.nih.gov/pubmed/31022191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0215381
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