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Loss of Sirt1 Function Improves Intestinal Anti-Bacterial Defense and Protects from Colitis-Induced Colorectal Cancer
Dysfunction of Paneth and goblet cells in the intestine contributes to inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Here, we report a role for the NAD(+)-dependent histone deacetylase SIRT1 in the control of anti-bacterial defense. Mice with an intestinal specific...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Public Library of Science
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4094521/ https://ncbi.nlm.nih.gov/pubmed/25013930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102495 |
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