SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

BACKGROUND: SIRT2 belongs to a highly conserved family of NAD(+)-dependent deacylases, consisting of seven members (SIRT1–SIRT7), which vary in subcellular localizations and have substrates ranging from histones to transcription factors and enzymes. Recently SIRT2 was revealed to play an important r...

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Bibliografiske detaljer
Main Authors: Lo Sasso, Giuseppe, Menzies, Keir Joe, Mottis, Adrienne, Piersigilli, Alessandra, Perino, Alessia, Yamamoto, Hiroyasu, Schoonjans, Kristina, Auwerx, Johan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4114785/
https://ncbi.nlm.nih.gov/pubmed/25072851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103573
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