Loss of Sirt1 Function Improves Intestinal Anti-Bacterial Defense and Protects from Colitis-Induced Colorectal Cancer

Dysfunction of Paneth and goblet cells in the intestine contributes to inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Here, we report a role for the NAD(+)-dependent histone deacetylase SIRT1 in the control of anti-bacterial defense. Mice with an intestinal specific...

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Detalhes bibliográficos
Main Authors: Lo Sasso, Giuseppe, Ryu, Dongryeol, Mouchiroud, Laurent, Fernando, Samodha C., Anderson, Christopher L., Katsyuba, Elena, Piersigilli, Alessandra, Hottiger, Michael O., Schoonjans, Kristina, Auwerx, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094521/
https://ncbi.nlm.nih.gov/pubmed/25013930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102495
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