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Insulin Receptor Activation with Transmembrane Domain Ligands

Complementary surfaces are buried when peptide hormones, growth factors, or cytokines bind and activate cellular receptors. Although these extended surfaces provide high affinity and specificity to the interactions, they also present great challenges to the design of small molecules that might eithe...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Lee, Jongsoon, Miyazaki, Masaya, Romeo, Giulio R., Shoelson, Steven E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094086/
https://ncbi.nlm.nih.gov/pubmed/24867955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.578641
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