Insulin Receptor Activation with Transmembrane Domain Ligands

Complementary surfaces are buried when peptide hormones, growth factors, or cytokines bind and activate cellular receptors. Although these extended surfaces provide high affinity and specificity to the interactions, they also present great challenges to the design of small molecules that might eithe...

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Bibliographic Details
Main Authors: Lee, Jongsoon, Miyazaki, Masaya, Romeo, Giulio R., Shoelson, Steven E.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094086/
https://ncbi.nlm.nih.gov/pubmed/24867955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.578641
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