Insulin Receptor Activation with Transmembrane Domain Ligands

Complementary surfaces are buried when peptide hormones, growth factors, or cytokines bind and activate cellular receptors. Although these extended surfaces provide high affinity and specificity to the interactions, they also present great challenges to the design of small molecules that might eithe...

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Hlavní autoři: Lee, Jongsoon, Miyazaki, Masaya, Romeo, Giulio R., Shoelson, Steven E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094086/
https://ncbi.nlm.nih.gov/pubmed/24867955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.578641
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