Tyrosine 308 Is Necessary for Ligand-directed G(s) Protein-biased Signaling of β(2)-Adrenoceptor

Interaction of a given G protein-coupled receptor to multiple different G proteins is a widespread phenomenon. For instance, β(2)-adrenoceptor (β(2)-AR) couples dually to G(s) and G(i) proteins. Previous studies have shown that cAMP-dependent protein kinase (PKA)-mediated phosphorylation of β(2)-AR...

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Autori principali: Woo, Anthony Yiu-Ho, Jozwiak, Krzysztof, Toll, Lawrence, Tanga, Mary J., Kozocas, Joseph A., Jimenez, Lucita, Huang, Ying, Song, Ying, Plazinska, Anita, Pajak, Karolina, Paul, Rajib K., Bernier, Michel, Wainer, Irving W., Xiao, Rui-Ping
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094047/
https://ncbi.nlm.nih.gov/pubmed/24831005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.558882
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