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Consensus design of a NOD receptor leucine rich repeat domain with binding affinity for a muramyl dipeptide, a bacterial cell wall fragment

Repeat proteins have recently emerged as especially well-suited alternative binding scaffolds due to their modular architecture and biophysical properties. Here we present the design of a scaffold based on the consensus sequence of the leucine rich repeat (LRR) domain of the NOD family of cytoplasmi...

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Main Authors: Parker, Rachael, Mercedes-Camacho, Ana, Grove, Tijana Z
פורמט: Artigo
שפה:Inglês
יצא לאור: Blackwell Publishing Ltd 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4093954/
https://ncbi.nlm.nih.gov/pubmed/24659515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2461
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