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SDF-1 dynamically mediates megakaryocyte niche occupancy and thrombopoiesis at steady state and following radiation injury

Megakaryocyte (MK) development in the bone marrow progresses spatially from the endosteal niche, which promotes MK progenitor proliferation, to the sinusoidal vascular niche, the site of terminal maturation and thrombopoiesis. The chemokine stromal cell-derived factor-1 (SDF-1), signaling through CX...

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Detalles Bibliográficos
Main Authors: Niswander, Lisa M., Fegan, Katherine H., Kingsley, Paul D., McGrath, Kathleen E., Palis, James
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4093683/
https://ncbi.nlm.nih.gov/pubmed/24735964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-547638
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