SDF-1 dynamically mediates megakaryocyte niche occupancy and thrombopoiesis at steady state and following radiation injury

Megakaryocyte (MK) development in the bone marrow progresses spatially from the endosteal niche, which promotes MK progenitor proliferation, to the sinusoidal vascular niche, the site of terminal maturation and thrombopoiesis. The chemokine stromal cell-derived factor-1 (SDF-1), signaling through CX...

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Autors principals: Niswander, Lisa M., Fegan, Katherine H., Kingsley, Paul D., McGrath, Kathleen E., Palis, James
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2014
Matèries:
Platelets and Thrombopoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4093683/
https://ncbi.nlm.nih.gov/pubmed/24735964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-547638
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