miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve Polycomb-mediated repression

Specification of the T helper 17 (Th17) cell lineage requires a well defined set of transcription factors, but how these integrate with post-transcriptional and epigenetic programs to regulate gene expression is poorly understood. Here we found defective Th17 cell cytokine expression in miR-155-defi...

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Autors principals: Escobar, Thelma M., Kanellopoulou, Chrysi, Kugler, David G., Kilaru, Gokhul, Nguyen, Cuong K., Nagarajan, Vijayaraj, Bhairavabhotla, Ravikiran K., Northrup, Daniel, Zahr, Rami, Burr, Patrick, Liu, Xiuhuai, Zhao, Keji, Sher, Alan, Jankovic, Dragana, Zhu, Jinfang, Muljo, Stefan A.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4092165/
https://ncbi.nlm.nih.gov/pubmed/24856900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.03.014
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