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Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis

The immune system develops in waves during ontogeny, being initially populated by cells generated from fetal hematopoietic stem cells (HSCs) and later by cells derived from adult HSCs. Remarkably, the genetic programs that control these two distinct stem cell fates remain poorly understood. We repor...

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Bibliographic Details
Main Authors: Yuan, Joan, Nguyen, Cuong K., Liu, Xiuhuai, Kanellopoulou, Chrysi, Muljo, Stefan A.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471381/
https://ncbi.nlm.nih.gov/pubmed/22345399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1216557
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