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G-Protein Coupled Receptors Engage the Mammalian Hippo pathway through F-Actin: F-Actin, assembled in response to Galpha(12/13) induced RhoA-GTP, promotes dephosphorylation and activation of the YAP oncogene
The Hippo pathway, a cascade of protein kinases that inhibits the oncogenic transcriptional coactivators YAP and TAZ, was discovered in Drosophila as a major determinant of organ size in development. Known modes of regulation involve surface proteins that mediate cell-cell contact or determine epith...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4092039/ https://ncbi.nlm.nih.gov/pubmed/23450633 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201200163 |
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