Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers

Both the human pregnane X receptor (hPXR) and constitutive androstane receptor (hCAR) are capable of regulating CYP3A4 and CYP2B6 gene expression. However, the majority of currently identified CYP3A4 and CYP2B6 inducers are confirmed activators of hPXR but not hCAR. To compare these receptors with r...

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Detalhes bibliográficos
Main Authors: Faucette, Stephanie R., Zhang, Tong-Cun, Moore, Rick, Sueyoshi, Tatsuya, Omiecinski, Curtis J., LeCluyse, Edward L., Negishi, Masahiko, Wang, Hongbing
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091905/
https://ncbi.nlm.nih.gov/pubmed/17041008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.106.112136
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