Variability in Human Sensitivity to 1,3-Butadiene: Influence of Polymorphisms in the 5′-Flanking Region of the Microsomal Epoxide Hydrolase Gene (EPHX1)

The carcinogenic effects of 1,3-butadiene (BD), a mutagenic chemical widely used in the manufacture of synthetic rubber, are likely initiated through its epoxide metabolites. In humans, these epoxides are detoxified predominantly by hydrolysis, a reaction mediated by the microsomal epoxide hydrolase...

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Autores principales: Abdel-Rahman, Sherif Z., Ammenheuser, Marinel M., Omiecinski, Curtis J., Wickliffe, Jeffrey K., Rosenblatt, Judah I., Ward, Jonathan B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2005
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091891/
https://ncbi.nlm.nih.gov/pubmed/15716486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfi115
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