IL-3/GM-CSF receptor promotes stem cell expansion, monocytosis, and atheroma macrophage burden in mice with hematopoietic Apoe deficiency

OBJECTIVE: Coronary heart disease is associated with monocytosis. Studies using animal models of monocytosis and atherosclerosis such as Apoe(-/-) mice have shown bone marrow (BM) hematopoietic stem and multi-potential progenitor cell (HSPC) expansion, associated with increased cell surface expressi...

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Main Authors: Wang, Mi, Subramanian, Manikandan, Abramowicz, Sandra, Murphy, Andrew J., Gonen, Ayelet, Witztum, Joseph, Welch, Carrie, Tabas, Ira, Westerterp, Marit, Tall, Alan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091799/
https://ncbi.nlm.nih.gov/pubmed/24651678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.113.303097
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