Hypercholesterolemia and reduced HDL-C promote hematopoietic stem cell proliferation and monocytosis: studies in mice and FH children

Previous studies have shown that mice with defects in cellular cholesterol efflux show hematopoietic stem cell (HSPC) and myeloid proliferation, contributing to atherogenesis. We hypothesized that the combination of hypercholesterolemia and defective cholesterol efflux would promote HSPC expansion a...

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Autori principali: Tolani, Sonia, Pagler, Tamara A., Murphy, Andrew J., Bochem, Andrea E., Abramowicz, Sandra, Welch, Carrie, Nagareddy, Prabhakara R., Holleran, Steve, Hovingh, G.K., Kuivenhoven, Jan Albert, Tall, Alan R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691284/
https://ncbi.nlm.nih.gov/pubmed/23684512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2013.03.031
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