Hypercholesterolemia and reduced HDL-C promote hematopoietic stem cell proliferation and monocytosis: studies in mice and FH children

Previous studies have shown that mice with defects in cellular cholesterol efflux show hematopoietic stem cell (HSPC) and myeloid proliferation, contributing to atherogenesis. We hypothesized that the combination of hypercholesterolemia and defective cholesterol efflux would promote HSPC expansion a...

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Detalhes bibliográficos
Main Authors: Tolani, Sonia, Pagler, Tamara A., Murphy, Andrew J., Bochem, Andrea E., Abramowicz, Sandra, Welch, Carrie, Nagareddy, Prabhakara R., Holleran, Steve, Hovingh, G.K., Kuivenhoven, Jan Albert, Tall, Alan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691284/
https://ncbi.nlm.nih.gov/pubmed/23684512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2013.03.031
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