ERBB2 overexpression suppresses stress-induced autophagy and renders ERBB2-induced mammary tumorigenesis independent of monoallelic Becn1 loss

Defective autophagy has been implicated in mammary tumorigenesis, as the gene encoding the essential autophagy regulator BECN1 is deleted in human breast cancers and Becn1(+/−) mice develop mammary hyperplasias. In agreement with a recent study, which reports concurrent allelic BECN1 loss and ERBB2...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Lozy, Fred, Cai-McRae, Xiaofeng, Teplova, Irina, Price, Sandy, Reddy, Anupama, Bhanot, Gyan, Ganesan, Shridar, Vazquez, Alexei, Karantza, Vassiliki
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Translational Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091153/
https://ncbi.nlm.nih.gov/pubmed/24492513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.27867
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados