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Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer

Hereditary breast cancers stem from germline mutations in susceptibility genes such as BRCA1, BRCA2 and PALB2, whose products function in the DNA damage response and redox regulation. Autophagy is an intracellular waste disposal and stress mitigation mechanism important for alleviating oxidative str...

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Detalhes bibliográficos
Main Authors: Huo, Yanying, Cai, Hong, Teplova, Irina, Bowman-Colin, Christian, Chen, Guanghua, Price, Sandy, Barnard, Nicola, Ganesan, Shridar, Karantza, Vassiliki, White, Eileen, Xia, Bing
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740014/
https://ncbi.nlm.nih.gov/pubmed/23650262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0011
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