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Sugars boost exhausted tumor-infiltrating lymphocytes by counteracting immunosuppressive activities of galectins
Galectins released by tumor cells and macrophages can bind surface glycoproteins of tumor-infiltrating lymphocytes (TILs), forming glycoprotein-galectin lattices with immunosuppressive activities. Specifically, TILs covered by galectin-3 are unable to secrete cytokines after stimulation. Treating TI...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4091051/ https://ncbi.nlm.nih.gov/pubmed/25097806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.28783 |
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