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CD39: A complementary target to immune checkpoints to counteract tumor-mediated immunosuppression
We report that CD39–expressing-melanoma cells inhibited both T-cell proliferation and the generation of cytotoxic effectors in an adenosine-dependent manner, and that treatment with a CD39-blocking antibody alleviated tumor-mediated immunosuppression. Thus, blocking CD39 ectonucleotidase may represe...
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| Publié dans: | Oncoimmunology |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Taylor & Francis
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4485743/ https://ncbi.nlm.nih.gov/pubmed/26155397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2014.1003015 |
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