CD39: A complementary target to immune checkpoints to counteract tumor-mediated immunosuppression

We report that CD39–expressing-melanoma cells inhibited both T-cell proliferation and the generation of cytotoxic effectors in an adenosine-dependent manner, and that treatment with a CD39-blocking antibody alleviated tumor-mediated immunosuppression. Thus, blocking CD39 ectonucleotidase may represe...

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Published in:Oncoimmunology
Main Authors: Bonnefoy, Nathalie, Bastid, Jérémy, Alberici, Gilles, Bensussan, Armand, Eliaou, Jean-François
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485743/
https://ncbi.nlm.nih.gov/pubmed/26155397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2014.1003015
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