A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion

Surface galectin has been shown to contribute to dysfunctions of human tumour-infiltrating lymphocytes (TILs). We show here that galectin-covered CD8 TILs produce normal amounts of intracellular cytokines, but fail to secrete them because of defective actin rearrangements at the synapse. The non-sec...

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Udgivet i:Nat Commun
Main Authors: Petit, Anne-Elisabeth, Demotte, Nathalie, Scheid, Benoît, Wildmann, Claude, Bigirimana, René, Gordon-Alonso, Monica, Carrasco, Javier, Valitutti, Salvatore, Godelaine, Danièle, van der Bruggen, Pierre
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961845/
https://ncbi.nlm.nih.gov/pubmed/27447355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12242
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