Age-Stratified Phase I Trial of a Combination of Bortezomib, Gemcitabine, and Liposomal Doxorubicin in Patients with Advanced Malignancies

BACKGROUND: Preclinical data suggest synergistic activity of bortezomib, gemcitabine, and liposomal doxorubicin. Because tolerance to therapy may be attenuated in elderly patients, we performed an age-stratified phase I trial of this combination. PATIENTS AND METHODS: Two parallel age-stratified arm...

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Huvudupphovsmän: Falchook, G. S., Duvic, M., Hong, D. S., Wheler, J., Naing, A., Lim, J., Kurzrock, R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091047/
https://ncbi.nlm.nih.gov/pubmed/22205203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-011-1808-4
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