Novel phase I study combining G1 phase, S phase, and G2/M phase cell cycle inhibitors in patients with advanced malignancies

PURPOSE: Cancer is a manifestation of aberrant cellular proliferation, and the cell cycle is one of the most successfully drugged targets in oncology. No prior study has been reported that simultaneously targets the 3 principal cell cycle phases populated by proliferating cells - G(1), S, and G(2)/M...

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Publicat a:Cell Cycle
Autors principals: Jain, Rajul K, Hong, David S, Naing, Aung, Wheler, Jennifer, Helgason, Thorunn, Shi, Nai-Yi, Gad, Yash, Kurzrock, Razelle
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2015
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Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825574/
https://ncbi.nlm.nih.gov/pubmed/26467427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1090065
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