A phase I study of the safety and pharmacokinetics of trabectedin in combination with pegylated liposomal doxorubicin in patients with advanced malignancies

Background: To determine the maximum tolerated dose (MTD), safety, potential pharmacokinetic (PK) interactions, and effect on liver histology of trabectedin in combination with pegylated liposomal doxorubicin (PLD) for advanced malignancies. Patients and methods: Entry criteria for the 36 patients i...

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Bibliografske podrobnosti
Main Authors: von Mehren, M., Schilder, R. J., Cheng, J. D., Temmer, E., Cardoso, T. M., Renshaw, F. G., Bayever, E., Zannikos, P., Yuan, Z., Cohen, R. B.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2008
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2598415/
https://ncbi.nlm.nih.gov/pubmed/18497430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdn363
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